Inflammation as a Leading Cause of Chronic Disease

Chronic inflammation is now thought to play a key pathogenetic role in the associations of obesity with insulin resistance and diabetes.

Data from the National Health and Nutrition Examination Survey (NHANES) 1999-2002 revealed strong associations of serum concentrations of persistent organic pollutants (POPs) with type 2 diabetes.  It is well-known that exposure to high concentrations of environmental pollutants can induce inflammation.

In this study, we observed that serum concentrations of OC pesticides were positively associated with C-Reactive Protein among the general population of the U.S. with background exposure to POPs.

There is no question that the exposure to certain environmental pollutants can induce inflammation. At present, the most studied area in both experimental and human studies subsumes the association between exposure to air pollution and system inflammation.

As an entirely nonspecific response to most forms of tissue damage, various factors may be involved in the chronic elevation of CRP. Our study suggested that, without consideration of exposure to POPs, CRP may not be associated with insulin resistance.